In Vitro Impact of FSH Glycosylation Variants on FSH Receptor-stimulated Signal Transduction and Functional Selectivity
نویسندگان
چکیده
منابع مشابه
FSH LH : FSH ratio
Patient A was a 30-year-old white woman with a longstanding history of primary amenorrhea and infertility. By age 18 the patient had neither menstruated nor demonstrated evidence of normal breast development. At that time she was given oral contraceptives for four cycles and responded with normal vaginal bleeding. Laboratory evaluation at age 18 demonstrated a serum FSH (follicle-stimulating ho...
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BACKGROUND The follicle-stimulating hormone receptor (FSH-R) is a seven transmembrane spanning receptor (7TMR) which plays a crucial role in male and female reproduction. Upon FSH stimulation, the FSH-R activates the extracellular signal-regulated kinases (ERK). However, the mechanisms whereby the agonist-stimulated FSH-R activates ERK are poorly understood. In order to activate ERK, some 7 TMR...
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The gonadotropin known as follicle-stimulating hormone (FSH) plays a key role in regulating reproductive processes. Physiologically active FSH is a glycoprotein that can accommodate glycans on up to four asparagine residues, including two sites in the FSHα subunit that are critical for biochemical function, plus two sites in the β subunit, whose differential glycosylation states appear to corre...
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Because the ovarian response to FSH stimulation in assisted reproduction is variable, ranging from hyporesponse to hyperresponse, with the possible complication of ovarian hyperstimulation, it would be of great benefit to predict the response of the patients to FSH. To date, no clear-cut predictors of ovarian responsiveness to FSH have been identified. In this study, we investigated the role of...
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Follicle stimulating hormone (FSH) is a glycoprotein hormone with subunitsαandβ, and is required for gamete development. Differential glycosylation may produce diglycosylated FSH with higher biological activity, and is suspected to be generated via the action of oligosaccharyltransferase(OST) isoforms. Signal peptide hydrophobicity of α and β maycontribute to selective usage of OST, and hence m...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2020
ISSN: 2472-1972
DOI: 10.1210/jendso/bvaa019